The Bible talks about the earthly nature versus the heavenly nature, the fleshly desires versus the heavenly desires, and pleasing God or self:
Do not be deceived: God cannot be mocked. A man reaps what he sows. The one who sows to please his sinful nature, from that nature will reap destruction; the one who sows to please the Spirit, from the Spirit will reap eternal life. Galatians 6:7-8
We must live to please God, not ourselves—but the incredible, divinely designed paradox is… if you please God, you are blessed; if you please your flesh, you are ironically destroying yourself. Go figure! I am continually in bewilderment at His brilliance.